An Evaluation Of The Nih Clinical Trial Registry - 1777 Words

Introduction The number of older individuals undergoing HSCT for malignant disease has risen considerably over the years. Between 2007- 2013, 22% of allogeneic transplants and 44% of autologous transplants were in patients older than 60 years of age1. The rise of HSCT in this age group can be attributed to the use of reduced intensity conditioning (RIC) regimen and advances in post-HSCT supportive care2,3. HSCT is a potential curative treatment for a number of malignant hematologic diseases such as myelodysplastic syndrome (MDS), leukemia, lymphoma and myeloma which tend to more commonly affect the elderly population. For instance, according to the SEER database, the median age of diagnosis of acute myeloid leukemia (AML) and MDS are 67 and 70 years respectively. Despite these findings, the number of patients over the age of 65 undergoing allogeneic HSCT remains low4. An evaluation of the NIH clinical trial registry revealed that 90% of HSCT clinical trials excluded older individuals (75 years), 75% based on chronologic age, 39% based on performance status in the elderly and 39% based on organ function in the elderly5. Inadequate accrual remains a problem even for trials that allow older patients, mostly due to physician reluctance, comorbidities and performance status6. Low rates of HSCT in the elderly and poor enrollment in HSCT clinical trials appear to be due to concerns regarding certain patient factors. Increasing age is associated with higher incidence of comorbidShow MoreRelatedStudy On Breast Cancer Management Guidelines Essay1584 Words   |  7 PagesMANAGEMENT GUIDELINES ABSTRACT- Cancer is a big cause of death worldwide. Around the world Cancer of different types effect millions of population and leads to loss of lives. According to the available data through our complete and thorough nationwide registries on cancer (number of times something happens), number and death in India among males cancers of lung, mouth, oesophagus and stomach are leading places/locations of cancer and among females cancer of breast, cervix are leading places/locations. BooksRead MoreA Brief Note On Lou Gehrig, The Greatest New York Yankee Baseball1967 Words   |  8 Pagesfor ubiquitin, and TAR DNA-binding protein (TDP-43). These inclusions lead to cell dysfunction and apoptosis (cell death). At autopsy the dorsal lateral spinal cord is gliotic and sclerotic; hence, lateral sclerosis (Ricks, 2005). Symptoms/ Clinical Features The Onset of ALS varies in anatomic location but disease progression is constant and linear. Changes are noted on a weekly or monthly basis. Many patients initially present with complaints of subtle focal weakness, stiff musclesRead MoreMedicare Policy Analysis447966 Words   |  1792 Pages089200 PO 00000 Frm 00064 Fmt 6652 Sfmt 6201 E:\BILLS\H3962.IH H3962 65 1 and emerging research and careful sci- 2 entific reviews, including the Guide to 3 Community 4 Guide to Clinical Preventative Services, 5 and the National Registry for Effective 6 Programs, and Preventative Services, the 7 (iii) includes strategies which focus on 8 prevention and support for employee popu- 9 lations at risk of poor health outcomes